Acetic Acid → HCID 68217632, compound

Participants

Reaction Steps

The mixture of compound 6-Fluoro-indan-1-one (5 g, 0.03 mol), and ethyl cyanoacetate (5 g, 0.05 mol), ammonium acetate (25 g, 0.33 mol) and glacial acetic acid (50 ml) in toluene (205 ml) was refluxed with a Dean Stark water trap for 4 h. The mixture was concentrated in vacuo, the residue washed by water and EtOH three times to afford the the compound (8.00 g, y=97.96%).

Provenance & Evidence