Ether hydrochloride → 5-(5-(3-(5-fluoro-2,3-dihydrospiro[indene-1,3'-pyrrolidine]-1'-yl)propylthio)-4-methyl-4H-1,2,4-triazol-3-yl)-2,4-dimethylthiazole hydrochloride

HRID 1661077Notes

Reaction equation

HRID 1661077 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:29](=[CH:30][CH:31]=1)[C:7]1([CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][S:15][C:16]3[N:17]([CH3:28])[C:18]([C:21]4[S:25][C:24]([CH3:26])=[N:23][C:22]=4[CH3:27])=[N:19][N:20]=3)[CH2:8]1)[CH2:6][CH2:5]2.[ClH:32].CCOCC>CCOCC.CO>[ClH:32].[F:1][C:2]1[CH:3]=[C:4]2[C:29](=[CH:30][CH:31]=1)[C:7]1([CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][S:15][C:16]3[N:17]([CH3:28])[C:18]([C:21]4[S:25][C:24]([CH3:26])=[N:23][C:22]=4[CH3:27])=[N:19][N:20]=3)[CH2:8]1)[CH2:6][CH2:5]2

Participants

5

Reactant 2

HCID 10953452Ether hydrochlorideHCID 247585915-(5-(3-(5-fluoro-2,3-dihydrospiro[indene-1,3'-pyrrolidine]-1'-yl)propylthio)-4-methyl-4H-1,2,4-triazol-3-yl)-2,4-dimethylthiazole

Product 1

HCID 247585925-(5-(3-(5-fluoro-2,3-dihydrospiro[indene-1,3'-pyrrolidine]-1'-yl)propylthio)-4-methyl-4H-1,2,4-triazol-3-yl)-2,4-dimethylthiazole hydrochlorideYield 73%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

To a solution of 5-(5-(3-(5-fluoro-2,3-dihydrospiro[indene-1,3′-pyrrolidine]-1′-yl)propylthio)-4-methyl-4H-1,2,4-triazol-3-yl)-2,4-dimethylthiazole (Prep18, 38 mg) in a mixture of Et2O (3 ml) and methanol (0.5 ml) was added 0.1 ml of HCl/Ether (1M in Et2O), the solvent was evaporated in vacuo and treated with Et2O (5 ml) to give 30 mg of the title compound (y=73%).

Workup

  1. customthe solvent was evaporated in vacuo
  2. additiontreated with Et2O (5 ml)

Sources & evidence

ORD record
ord-458234da756841faa0e389c47b704897
Source dataset
uspto-grants-2011_10
Patent number
US08030322B2

Reaction notes

Loading…