Potassium Hydroxide → HCID 67429636, compound

Participants

Reaction Steps

0.2 g of 5-iodo-2H-isoquinolin-1-one, 234 mg of 4-bromoheptane, 62 mg of finely ground potassium hydroxide, 79 mg of tetrabutylammonium bromide then 28 cm3 of toluene are stirred, under an inert atmosphere, for 6 h at the reflux of the solvent. The reaction mixture is filtered through sintered glass. The filtrate is concentrated using a rotary evaporator under reduced pressure (5 kPa). The 320 mg of brown oil obtained are purified by flash chromatography over silica (column: 35 g; particle size: 20-40 μm, spherical; eluent: 80% heptane/20% ethyl acetate). After concentrating the fractions under reduced pressure, 165 mg of 5-iodo-2-(1-propylbutyl)isoquinolin-1(2H)-one are obtained in the form of a yellow solid.

Provenance & Evidence