Hydrochloric Acid → N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)-1,2-dihydroisoquinoline-5-carboxamide hydrochloride

Participants

Reaction Steps

84 mg of N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]-amino}propyl]-1-oxo-2-(1-propylbutyl)-1,2-dihydroisoquinoline-5-carboxamide are dissolved in 4 cm3 of ethyl ether at a temperature close to 20° C. 0.2 cm3 of a 4M solution of hydrochloric acid in dioxane is added while stirring and under argon. The reaction mixture precipitates. The stirring is stopped. The supernatant is removed and 5 cm3 of ethyl ether are added. This operation is carried out three times. The last suspension is concentrated under reduced pressure (5 kPa). 87 mg of N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-1-oxo-2-(1-propylbutyl)-1,2-dihydroisoquinoline-5-carboxamide hydrochloride (1:1) are obtained in the form of a white solid.

Provenance & Evidence