1-(Propan-2-yl)-1,3-dihydro-2H-benzimidazol-2-one → HCID 68584613, compound

HRID 16611Notes

Reaction equation

HRID 16611 reaction equation
[CH:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[NH:6][C:5]1=[O:13])([CH3:3])[CH3:2].[CH2:14]([O:21][C:22]([C:24]1([CH2:30][N:31]2[CH2:36][CH2:35][C:34]([CH2:38][NH:39][C:40](=O)[O:41]C(C)(C)C)([F:37])[CH2:33][CH2:32]2)[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1)=[O:23])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([O:21][C:22]([C:24]1([CH2:30][N:31]2[CH2:32][CH2:33][C:34]([CH2:38][NH:39][C:40]([N:6]3[C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=4[N:4]([CH:1]([CH3:3])[CH3:2])[C:5]3=[O:13])=[O:41])([F:37])[CH2:35][CH2:36]2)[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1)=[O:23])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 16535801-(Propan-2-yl)-1,3-dihydro-2H-benzimidazol-2-oneHCID 86602124HCID 86602124, compound

Product 1

HCID 68584613HCID 68584613, compound

Procedure

The title compound was prepared according to the procedure described in step 6 of Example 1 from 1-isopropyl-1,3-dihydro-2H-benzimidazol-2-one and tert-Butyl ({1-[(4-benzyoxyarbonyltetrahydro-2H-pyran-4-yl)methyl]-4-fluoropiperidin-4-yl}methyl)carbamate (step 5 of Example 15).

Sources & evidence

ORD record
ord-566a8bf40f664e8da7b072aecd1843dd
Source dataset
uspto-grants-2010_06
Patent number
US07737163B2

Reaction notes

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