HRID16611

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1653580

1-(Propan-2-yl)-1,3-dihydro-2H-benzimidazol-2-one

C10H12N2O

结构：CC(C)(C)OC(=O)NCC1(F)CCN(CC2(C(=O)OCc3ccccc3)CCOCC2)CC1

HCID86602124

未命名化合物

PRODUCTS

生成物

结构：CC(C)n1c(=O)n(C(=O)NCC2(F)CCN(CC3(C(=O)OCc4ccccc4)CCOCC3)CC2)c2ccccc21

HCID68584613

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the procedure described in step 6 of Example 1 from 1-isopropyl-1,3-dihydro-2H-benzimidazol-2-one and tert-Butyl ({1-[(4-benzyoxyarbonyltetrahydro-2H-pyran-4-yl)methyl]-4-fluoropiperidin-4-yl}methyl)carbamate (step 5 of Example 15).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-566a8bf40f664e8da7b072aecd1843dd
来源数据集: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07737163B2
来源说明: uspto-grants-2010_06

反应 SMILES

[CH:1]([N:4]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[NH:6][C:5]1=[O:13])([CH3:3])[CH3:2].[CH2:14]([O:21][C:22]([C:24]1([CH2:30][N:31]2[CH2:36][CH2:35][C:34]([CH2:38][NH:39][C:40](=O)[O:41]C(C)(C)C)([F:37])[CH2:33][CH2:32]2)[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1)=[O:23])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([O:21][C:22]([C:24]1([CH2:30][N:31]2[CH2:32][CH2:33][C:34]([CH2:38][NH:39][C:40]([N:6]3[C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=4[N:4]([CH:1]([CH3:3])[CH3:2])[C:5]3=[O:13])=[O:41])([F:37])[CH2:35][CH2:36]2)[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1)=[O:23])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1