Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To a round bottom flask was added (S)—((S)-1-(8-(4-chlorophenyl)-5-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methyl)-6-oxo-7-phenyl-5,6-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl) 2-( tert-butoxycarbonylamino)-3-methylbutanoate (39 mg, 0.529 mmol) and 4N HCl (2 ml). The reaction was stirred at rt for 30 min. After this time, the solution was concentrated under reduced pressure. To the residue was added CH2Cl2(2 ml) and hexanes (2 ml). The solvent was decanted. The remaining solid was dried under vacuum to give product (S)—((S)-1-(8-(4-chlorophenyl)-5-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methyl)-6-oxo-7-phenyl-5,6-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl) 2-amino-3-methylbutanoate as an HCl salt (30mg, 85% yield).

Provenance & Evidence