Phosphorus oxychloride → HCID 66858598, compound

Participants

Reaction Steps

Phosphorylchloride (0.25 ml; 200 μmol) was added to a solution of 2,2-Dimethylpropionic acid 4-(3-benzyloxy-17-hydroxy-17-trifluoromethyl-estra-1,3,5(10)-trien-15-yl)-butylester (80.0 mg; 136 μmol) in pyridine (2.50 ml) and the resulting mixture is heated under reflux for 24 h. Then, the mixture was allowed to cool to RT, diluted with ice water and extracted with ether. The combined organic phases were dried over MgSO4 and the solvent was evaporated. The residue was purified by column chromatography (SiO2, DCM) yielding the title compound (60.0 mg, 78%) as colourless oil.

Provenance & Evidence