4-Fluorobenzoyl chloride → HCID 3225919, compound

HRID 1661172Notes

Reaction equation

HRID 1661172 reaction equation
F[C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.Cl.[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[N:23]=[C:22]([CH:24]3[CH2:29][CH2:28][CH2:27][NH:26][CH2:25]3)[O:21][N:20]=2)=[CH:15][CH:14]=1>C(Cl)Cl.CO>[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]2[N:23]=[C:22]([CH:24]3[CH2:29][CH2:28][CH2:27][N:26]([C:6]([C:5]4[CH:9]=[CH:10][CH:2]=[CH:3][CH:4]=4)=[O:7])[CH2:25]3)[O:21][N:20]=2)=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 47002965HCID 47002965, compound

Product 1

HCID 3225919HCID 3225919, compoundYield 30%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The compound was prepared following the procedure described in the Example 3 (D), using 4-Fluoro-benzoyl chloride as the acyl chloride of choice and the 3-[3-(4-Fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidine hydrochloride (already prepared before in the Example 4 (B)). Yield: 30% (white powder); mp=82-83° C.; Rf=0.25 DCM/MeOH:98/2);

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-5e9f9f290ca94fbda15cec6c7240417e
Source dataset
uspto-grants-2011_10
Patent number
US08030331B2

Reaction notes

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