2-Bromo-4-methylpyridine → 3'-[4-(4-Methyl-pyridine-2-carbonyl)-imidazol-1-yl]-biphenyl-2-carbonitrile
Reaction equation
CON(C)[C:4]([C:6]1[N:7]=[CH:8][N:9]([C:11]2[CH:12]=[C:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]#[N:24])[CH:14]=[CH:15][CH:16]=2)[CH:10]=1)=[O:5].Br[C:27]1[CH:32]=[C:31]([CH3:33])[CH:30]=[CH:29][N:28]=1>>[CH3:33][C:31]1[CH:30]=[CH:29][N:28]=[C:27]([C:4]([C:6]2[N:7]=[CH:8][N:9]([C:11]3[CH:12]=[C:13]([C:17]4[C:18]([C:23]#[N:24])=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH:14]=[CH:15][CH:16]=3)[CH:10]=2)=[O:5])[CH:32]=1Participants
3
Procedure
This compound is prepared by method C using compound 12d and 2-bromo-4-methylpyridine.
Workup
- customThis compound is prepared by method C
Sources & evidence
- ORD record
- ord-d16c853bc2b04292ba1a952adad56eff
- Source dataset
- uspto-grants-2011_10
- Patent number
- US08030339B2
Reaction notes
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