HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylpropanolamine → (1R,2S)-1-[1-(4-fluorophenyl)indazol-4-yl]oxy-1-phenyl-propan-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylpropanolamine | HCID 10297 | — |
| Reactant | (alphaS,betaR)-beta-{[1-(4-Fluorophenyl)-1H-indazole-5-yl]oxy}-alpha-methylbenzeneethanamine | HCID 59339817 | — |
| Reactant | 4-Iodo-1-(4-fluorophenyl)indazole | HCID 66687817 | — |
| Product | (1R,2S)-1-[1-(4-fluorophenyl)indazol-4-yl]oxy-1-phenyl-propan-2-amine | HCID 66687159 | — |
Reaction Steps
Prepared according to the protocol described for 1a starting from 4-iodo-1-(4-fluorophenyl)indazole (3b, 332 mg, 0.98 mmol) and (1R,2S)-norephedrine (742 mg, 4.9 mmol). Yield: 150 mg (42%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030340B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-b76251966238409cbed65a353b4c6ddd |
| Source note | uspto-grants-2011_10 |