Methanesulfonyl chloride → N-[(1R,2S)-1-phenyl-1-(1-propan-2-ylindazol-5-yl)oxy-propan-2-yl]methanesulfonamide

HRID 1661454Notes

Reaction equation

HRID 1661454 reaction equation
[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([O:13][C@H:14]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[C@@H:15]([NH2:17])[CH3:16])=[CH:10][CH:11]=2)[CH:6]=[N:5]1)([CH3:3])[CH3:2].[CH3:24][S:25](Cl)(=[O:27])=[O:26]>>[C:18]1([C@@H:14]([O:13][C:9]2[CH:8]=[C:7]3[C:12](=[CH:11][CH:10]=2)[N:4]([CH:1]([CH3:2])[CH3:3])[N:5]=[CH:6]3)[C@@H:15]([NH:17][S:25]([CH3:24])(=[O:27])=[O:26])[CH3:16])[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 59339639(1R,2S)-1-[(1-isopropyl-1H-indazol-5-yl)oxy]-1-phenylpropan-2-amine

Product 1

HCID 24954948N-[(1R,2S)-1-phenyl-1-(1-propan-2-ylindazol-5-yl)oxy-propan-2-yl]methanesulfonamide

Procedure

The title compound was prepared from (1R,2S)-1-[(1-isopropyl-1H-indazol-5-yl)oxy]-1-phenylpropan-2-amine (30b, 31 mg, 100 μmol) and methanesulfonyl chloride (34 mg, 300 μmol) as described in Example 2b. Yield 28 mg (72%).

Sources & evidence

ORD record
ord-bc558e4a3ed249348be38d2b3c23610c
Source dataset
uspto-grants-2011_10
Patent number
US08030340B2

Reaction notes

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