化工社化工社 化学情報印刷レポート · 研究参考用
2-Bromopropane → 5-iodo-1-isopropyl-1H-indazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Bromopropane | HCID 6358 | — |
| 反応物 | 5-Iodo-1H-indazole | HCID 21894739 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 5-iodo-1-isopropyl-1H-indazole | HCID 59339864 | 52% |
| 生成物 | 5-iodo-2-isopropyl-2H-indazole | HCID 66687875 | 40% |
反応手順
A mixture of 5-iodo-1H-indazole (488 mg, 2 mmol), isopropyl bromide (244 mg, 2 mmol), and KOtBu (336 mg, 3 mmol) in dry DMF (4 ml) was stirred at room temp. overnight. Then it was diluted with ethyl acetate (50 ml), washed with water (2×50 ml), and dried with Na2SO4. Evaporation of solvent and purification by flash chromatography on silica gel (n-heptane/ethyl acetate) afforded the subtitle compound (298 mg, 52%) along with 5-iodo-2-isopropyl-2H-indazole (227 mg, 40%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08030340B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-57c40bcdf2c846aca8d2f0c5815ccbd2 |
| 出典メモ | uspto-grants-2011_10 |