m-Chloroperbenzoic acid → HCID 59786558, compound

Participants

Reaction Steps

N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methylsulfanylphenyl)propan-2-yl]cyclopropanesulfonamide (29, 20.5 mg, 0.04 mmol) was dissolved in DCM (2 mL) and cooled in an ice bath. 3-Chloroperbenzoic acid (70-75%) (10 mg, 0.04 mmol) dissolved in DCM (0.1 mL) was added. The reaction was stirred for 30 min, quenched by addition of 10% Na2SO3 solution (0.5 mL). Purification by HPLC and freeze drying of fractions with product gave the title compound as a colourless solid. Yield 17 mg (80%).

Provenance & Evidence