Cyclopropanesulfonyl chloride → HCID 24954949, compound

HRID 1661458Notes

Reaction equation

HRID 1661458 reaction equation
[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][C:11]([O:15][C@H:16]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[C@@H:17]([NH2:19])[CH3:18])=[CH:12][CH:13]=3)[CH:8]=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:26]1([S:29](Cl)(=[O:31])=[O:30])[CH2:28][CH2:27]1>>[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][C:11]([O:15][C@H:16]([C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=4)[C@@H:17]([NH:19][S:29]([CH:26]4[CH2:28][CH2:27]4)(=[O:31])=[O:30])[CH3:18])=[CH:12][CH:13]=3)[CH:8]=[N:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 2760919Cyclopropanesulfonyl chlorideHCID 59339798(1R,2S)-1-[(1-cyclopentyl-1H-indazol-5-yl)oxy]-1-phenylpropan-2-amine

Product 1

HCID 24954949HCID 24954949, compound

Procedure

The title compound was prepared from (1R,2S)-1-[(1-cyclopentyl-1H-indazol-5-yl)oxy]-1-phenylpropan-2-amine (32b, 17 mg, 51 μmol) and cyclopropanesulfonyl chloride (34 mg, 153 μmol) as described in Example 2b. Yield 10 mg (45%).

Sources & evidence

ORD record
ord-80763cf0e3a2464aad2650368fb11737
Source dataset
uspto-grants-2011_10
Patent number
US08030340B2

Reaction notes

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