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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1661461Generated: October 25, 2026

Cyclopropanesulfonyl chloride → N-[(1RS,2RS)-1-[6-chloro-1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-fluorophenyl)propan-2-yl]cyclopropanesulfonamide

https://huagongshe.com/reaction/1661461

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclopropanesulfonyl chlorideHCID 2760919—
Reactant(1RS,2RS)-1-[6-chloro-1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-fluorophenyl)propan-2-amineHCID 59786589—
ProductN-[(1RS,2RS)-1-[6-chloro-1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-fluorophenyl)propan-2-yl]cyclopropanesulfonamideHCID 66687383—

Reaction Steps

Prepared according to the procedure described for Example 1 starting with (1RS,2SR)-1-[6-chloro-1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-fluorophenyl)propan-2-amine (35a-rac-2, 55 mg, 0.13 mmol) and cyclopropylsulphonyl chloride (42 μl, 0.4 mmol). Yield: 2 mg (3%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08030340B2
Source datasetuspto-grants-2011_10
ORD IDord-eaee2a501a2549d3a1b6fb5560ee27c5
Source noteuspto-grants-2011_10