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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1661463Generated: October 25, 2026

Cyclopropanesulfonyl chloride → N-[(1RS,2RS)-1-[6-chloro-1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-fluorophenyl)propan-2-yl]cyclopropanesulfonamide

https://huagongshe.com/reaction/1661463

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCyclopropanesulfonyl chlorideHCID 2760919—
Reactant(1RS,2RS)-1-[6-chloro-1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-fluorophenyl)propan-2-amineHCID 59786589—
ProductN-[(1RS,2RS)-1-[6-chloro-1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-fluorophenyl)propan-2-yl]cyclopropanesulfonamideHCID 66687383—

Reaction Steps

Prepared according to the procedure described for Example 1 starting with (1RS,2SR)-1-[6-chloro-1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-fluorophenyl)propan-2-amine (35a-rac-1, 35 mg, 0.08 mmol) and cyclopropylsulphonyl chloride (27 μl, 0.25 mmol). Yield: 2 mg (5%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08030340B2
Source datasetuspto-grants-2011_10
ORD IDord-041d3074824d449d8a3293668b883e21
Source noteuspto-grants-2011_10