反应详情

温度

-10 °C

To (2R,3R)-2-Methyl-3-phenylaziridine (38b, 0.08 g, 0.60 mmol) in CH2Cl2 (3 ml) was is added N,N-Diisopropylmethyamine (0.219 ml, 1.32 mmol) and the reaction mixture was cooled to −10° C. before methansulfonyl chloride (0.051 ml, 0.66 mmol) was added The mixture was stirred for 30 min at −10° C. than at room temperature for 1 h. The crude sample was added to a Chromasil C18 column and was eluted with MeCN/H2O 35-70%, 20 min.

1. additionwas added The mixture
2. additionThe crude sample was added to a Chromasil C18 column
3. washwas eluted with MeCN/H2O 35-70%, 20 min.