HCID 67429313, compound → HCID 24955307, compound

HRID 1661470Notes

Reaction equation

HRID 1661470 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][C@@H:18]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH2:19][NH2:20])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[Cl-].[CH:28]1([S:31](C2CC2)(=[O:33])=[O:32])[CH2:30][CH2:29]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([O:17][C@@H:18]([C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH2:19][NH:20][S:31]([CH:28]4[CH2:30][CH2:29]4)(=[O:33])=[O:32])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 67429313HCID 67429313, compoundHCID 86761423HCID 86761423, compound

Product 1

HCID 24955307HCID 24955307, compound

Procedure

Prepared according to the procedure described for Example 1 from [(1S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-ethan-2-amine (41a, 31 mg, 0.09 mmol) cyclopropylsulphone chloride (28 μl, 0.27 mmol). Yield: 22 mg (54%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-306860caf550472a887bfdbdcbe246f1
Source dataset
uspto-grants-2011_10
Patent number
US08030340B2

Reaction notes

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