참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 5-iodo-1-pyridin-3-yl-1H-indazole | HCID 59786571 | — |
| 반응물 | HCID 59786583 | HCID 59786583 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Butyronitrile | HCID 8008 | — |
| 생성물 | HCID 59786580 | HCID 59786580 | — |
반응 단계
5-Iodo-1-(3-pyridinyl)indazole (750 mg, 2.3 mmole), 2-Amino-1-[6-methoxypyridin-3-yl]propan-1-ol (410 mg, 2.2 mmol), copper(I)iodide (42 mg, 0.22 mmol) and caesium carbonate (1.45 g, 4.5 mmole) were suspended in butyronitrile (2.4 mL) and toluene (4.8 mL). The reaction vessel was capped and the mixture was stirred at 130° C. for 20 hours. Then the solvent was removed i.vac., and the product purified by chromatography on silica gel. Yield 254 mg (3 0%) as a racemic mixture of two diastereomeres.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08030340B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_10 |
|---|
| ORD ID | ord-394ddf0596ae4f78ab2d49184cb624cf |
|---|
| 출처 메모 | uspto-grants-2011_10 |
|---|
