HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → Diethylenetriaminepentaacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | Diethylenetriamine | HCID 8111 | — |
| Reactant | Ethyl trifluoroacetate | HCID 9794 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Product | Diethylenetriaminepentaacetic acid | HCID 3053 | — |
Reaction Steps
Various esters of DTPA were prepared from diethylenetriamine, 6. The primary amines could be selectively protected as the di-trifluoroacetamide by reaction with ethyl trifluoroacetate to produce 9 in good yield. Reaction of 9 with 3 equivalents of ethylbromoacetate and NaH produced the triester 10. Reaction of 9 with 1 equivalent of ethylbromoacetate produced the monoester 11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030358B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-cbc8fac7932c4470b56ef38e6be86d25 |
| Source note | uspto-grants-2011_10 |