Ethyl Acetate → HCID 68998580, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 500 mg (1.08 mmol) of (3S*,3aR*,8bR*)-3a-(4-chlorophenyl)-6,8-diethoxy-8b-hydroxy-3-phenyl-2,3,3a,8b-tetrahydrocyclopenta[b]benzofuran-1-one (Example 15A) and 1.08 ml (2.15 mmol) of a 2 M solution of methoxymagnesium methyl carbonate in DMF is heated with stirring at 100° C. in a closed vessel for 16 h. The resulting suspension is then poured into a mixture of ice-cold 5 N hydrochloric acid and ethyl acetate. The organic phase is separated off, washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered with suction and concentrated. 531 mg of crude product are employed directly in the next stage without further characterization.

Provenance & Evidence