Dimethylamine → HCID 11547212, compound

Participants

Reaction Steps

100 mg (0.22 mmol) of (1S*,3S*,3aR*,8bS*)-6-(2-chloroethoxy)-3a-(4-chlorophenyl)-3-phenyl-2,3,3a,8b-tetrahydrocyclopenta[b]benzofuran-1,8b-(1H)-diol (Example 48A) are heated in 10 ml of 33% strength ethanolic dimethylamine solution in a closed apparatus at 70° C. under argon overnight. Cooling is followed by concentration. Column chromatography on silica gel 60 (mobile phase: dichloromethane/methanol/triethylamine 95:5:1) results in 89 mg (87% of theory) of the product as racemic mixture.

Provenance & Evidence