Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-(5-Cyano-2-pyridin-3-yl-indole-1-carbonyl)-benzoic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 반응물 | 1,4-Benzenedicarboxylic acid, 1-butyl ester | HCID 74557 | — |
| 반응물 | 2-pyridin-3-yl-1H-indole-5-carbonitrile | HCID 44554135 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 생성물 | 4-(5-Cyano-2-pyridin-3-yl-indole-1-carbonyl)-benzoic acid tert-butyl ester | HCID 58215722 | — |
반응 단계
To 2-pyridin-3-yl-1H-indole-5-carbonitrile (575 mg, 2.62 mmol), 4-(butoxycarbonyl)benzoic acid (700 mg, 3.15 mmol) and DMAP (780 mg, 3.93 mmol) in DMF (30 mL) is added DCC (811 mg, 3.93 mmol). The reaction is stirred for 3 days and the mixture is poured into water (50 mL) and extracted with ethyl acetate, dried over Na2SO4 and concentrated. The residue is purified by silica gel flash chromatography (ethyl acetate-heptane gradient) to give 4-(5-cyano-2-pyridin-3-yl-indole-1-carbonyl)-benzoic acid tert-butyl ester as a white solid. MS (ESI) m/z 424 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08030334B2 |
| 출처 데이터셋 | uspto-grants-2011_10 |
| ORD ID | ord-246ac85c300343d3bd1c155dba15a7b9 |
| 출처 메모 | uspto-grants-2011_10 |