(1-Methyl-1H-indol-2-yl)boronic acid → morpholine-4-sulfonic acid 5-(1-methyl-1H-indol-2-yl)-pyridin-3-yl ester

HRID 1661658Notes

Reaction equation

HRID 1661658 reaction equation
Br[C:2]1[CH:3]=[C:4]([O:8][S:9]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)(=[O:11])=[O:10])[CH:5]=[N:6][CH:7]=1.[CH3:18][N:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[C:20]1B(O)O>>[CH3:18][N:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[C:20]1[C:2]1[CH:3]=[C:4]([O:8][S:9]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)(=[O:11])=[O:10])[CH:5]=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 22733820(1-Methyl-1H-indol-2-yl)boronic acidHCID 58215797Morpholine-4-sulfonic acid 5-bromo-pyridin-3-yl ester

Product 1

HCID 58215570morpholine-4-sulfonic acid 5-(1-methyl-1H-indol-2-yl)-pyridin-3-yl ester

Procedure

Morpholine-4-sulfonic acid 5-bromo-pyridin-3-yl ester and N-methyl-indoleboronic acid are processed according to the method described in Example 100 to give morpholine-4-sulfonic acid 5-(1-methyl-1H-indol-2-yl)-pyridin-3-yl ester. MS (ESI) m/z 374.1 (M+H)+

Sources & evidence

ORD record
ord-db23fcfa2dbe42159bf428f17b6fe69b
Source dataset
uspto-grants-2011_10
Patent number
US08030334B2

Reaction notes

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