(1-Methyl-1H-indol-2-yl)boronic acid → 4-Methyl-piperazine-1-sulfonic acid 5-(1-methyl-1H-indol-2-yl)-pyridin-3-yl ester

HRID 1661659Notes

Reaction equation

HRID 1661659 reaction equation
Br[C:2]1[CH:3]=[C:4]([O:8][S:9]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)(=[O:11])=[O:10])[CH:5]=[N:6][CH:7]=1.[CH3:19][N:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[C:21]1B(O)O>>[CH3:19][N:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[C:21]1[C:2]1[CH:3]=[C:4]([O:8][S:9]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)(=[O:11])=[O:10])[CH:5]=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 22733820(1-Methyl-1H-indol-2-yl)boronic acidHCID 582158234-Methyl-piperazine-1-sulfonic acid 5-bromo-pyridin-3-yl ester

Product 1

HCID 582156114-Methyl-piperazine-1-sulfonic acid 5-(1-methyl-1H-indol-2-yl)-pyridin-3-yl ester

Procedure

4-Methyl-piperazine-1-sulfonic acid 5-bromo-pyridin-3-yl ester and N-methyl-indoleboronic acid are processed according to the method described in Example 100 to give 4-Methyl-piperazine-1-sulfonic acid 5-(1-methyl-1H-indol-2-yl)-pyridin-3-yl ester. MS (ESI) m/z 387.1 (M+H)+.

Sources & evidence

ORD record
ord-6a61aeaadfb945f286594b4379fd5d00
Source dataset
uspto-grants-2011_10
Patent number
US08030334B2

Reaction notes

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