Hydrazine → HCID 57654519, compound

HRID 1661835Notes

Reaction equation

HRID 1661835 reaction equation
C([O:3][C:4](=O)[C:5]([C:8]1[CH:9]=[CH:10][C:11]2[O:15][CH:14]=[CH:13][C:12]=2[CH:16]=1)([F:7])[F:6])C.[NH2:18][NH2:19]>CO>[O:15]1[C:11]2[CH:10]=[CH:9][C:8]([C:5]([F:7])([F:6])[C:4]([NH:18][NH2:19])=[O:3])=[CH:16][C:12]=2[CH:13]=[CH:14]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 57654537HCID 57654537, compound

Product 1

HCID 57654519HCID 57654519, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of the compound prepared in step c (127 mg, 0.53 mmol) and hydrazine (0.28 mL, 8.9 mmol) in dry methanol (3 mL) was stirred at reflux for 3 hr, cooled to RT and evaporated in vacuo to afford a semisolid product (0.12 g) 99%. 1H NMR (400 MHz, DMSO-d6) δ 8.12 (s, 1H), 7.90 (s, 1H), 7.76 (d, J=9.1 Hz, 1H), 7.52 (dd, J=8.5, 1.5 Hz, 1H), 7.09 (d, J=1.3 Hz, 1H)

Workup

  1. temperatureat reflux for 3 hr
  2. customevaporated in vacuo

Sources & evidence

ORD record
ord-4a241003e4214e0098a756a7123bd833
Source dataset
uspto-grants-2011_10
Patent number
US08030305B2

Reaction notes

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