Sodium Lauryl Sulfate → Tacrolimus

Participants

Reaction Steps

Subsequently an analogous procedure was used to prepare the monooxime of tacrolimus. Tacrolimus was provided as a solid mixture in a capsule containing 1.02 mg of tacrolimus monohydrate and approximately a 6-fold excess of sodium dodecyl sulfate (SDS). The solid mixture from 30 capsules was combined and extracted 4 times with 12 ml each time of ethyl acetate. The combined organic extracts were concentrated under a vacuum to give 49 mg of crude tacrolimus which was used directly in the following reaction.

Provenance & Evidence