huagongshe.com
HRID1661874

反应详情

EQUATION

反应方程式

HRID 1661874 的结构方程式

REACTANTS

反应物

1
反应SMILES：CC1CCC(C(C)C)C(OC(=O)CC(NC(=O)OCc2ccccc2)(C(N)=O)C(=O)OC(C)(C)C)C1
HCID66704225

未命名化合物

PRODUCTS

产物

1
反应SMILES：CC1CCC(C(C)C)C(OC(=O)C[C@@](NC(=O)OCc2ccccc2)(C(N)=O)C(=O)OC(C)(C)C)C1
HCID66704172

未命名化合物

收率 8.8%

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

t-Butyl 2-benzyloxycarbonylamino-2-carbamoyl-3-[(−)-menthyloxycarbonyl]propionate (500 mg) was dissolved in acetone (2.5 g) under heating and placed in a freezer overnight. The precipitated crystals were filtered and dried to give t-butyl (2R)-2-benzyloxycarbonylamino-2-carbamoyl-3-[(−)-menthyloxycarbonyl]propionate (44 mg, yield 8.8%) as a white crystal. Optical purity of (2R)-derivative: 79.1% d.e.

WORKUP

后处理

  1. temperatureunder heating
  2. filtrationThe precipitated crystals were filtered
  3. customdried