2365144-97-2 → HCID 3087262, compound

Participants

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The study of acute daily toxicity of Compound I was carried out on white nondescript male mice with body weight 25-28 g, which lived in habitual conditions in vivarium and received feed and water ad libitum. Single dose of Compound I was administered intraperitoneally. The animals were under observation for 2 days after the dosing. The dose levels of Compound I used in the toxicity study were as follows: 800 mg/kg, 1000 mg/kg, 1200 mg/kg, 1500 mg/kg, 1600 mg/kg. Compound I was dissolved in distilled water and administered in 0, 1 ml per 10 g of the body weight of the animal when the doses 800 mg/kg and 1000 mg/kg, and in 0.2 ml per 10 g of the body weight when the doses 1200 mg/kg, 1500 mg/kg, 1600 mg/kg were used. Control animals received distilled water in the volume 0.2 ml per 10 g of the body weight.

Provenance & Evidence