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4-Bromo-2-methoxy-6-nitroaniline → 5-Bromo-3-methoxybenzene-1,2-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Bromo-2-methoxy-6-nitroaniline | HCID 50879056 | — |
| 触媒 | Platinum | HCID 23939 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | 5-Bromo-3-methoxybenzene-1,2-diamine | HCID 50879057 | 85.3% |
反応手順
A solution of 2.0 g (8.1 mmol) 4-Bromo-2-methoxy-6-nitro-phenylamine [Zhou, Q-T., et al. Huaxue Xuebao 1980, 38(5), 507-10] in 50 ml methanol/water (2:1) is hydrogenated in the presence of 200 mg Pt/C (Engelhard 4709) at normal pressure for 3 h. Then the catalyst is filtered off and the filtrate is concentrated in vacuo to afford 1.5 g of the title compound as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08030497B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-80a5c976bbc7422d9e897253f3b7e4af |
| 出典メモ | uspto-grants-2011_10 |