HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Bromo-2-methoxy-6-nitro-phenyl)-(2-methoxy-ethyl)-amine → 5-bromo-3-methoxy-2-N-(2-methoxyethyl)benzene-1,2-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Bromo-2-methoxy-6-nitro-phenyl)-(2-methoxy-ethyl)-amine | HCID 57772042 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-bromo-3-methoxy-2-N-(2-methoxyethyl)benzene-1,2-diamine | HCID 57772082 | — |
Reaction Steps
A solution of 6.19 (20 mmol) (4-bromo-2-methoxy-6-nitro-phenyl)-(2-methoxy-ethyl)-amine in 140 ml THF is hydrogenated in the presence of 1.4 g Raney-Nickel (B113W Degussa) at normal pressure for 25 h. The catalyst is filtered off and the filtrate is concentrated in vacuo. The residue is purified by flash-chromatography on silica gel (hexane:EtOAc=2:1) to afford 4.95 g of the title compound as a as a reddish oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08030497B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-62abb3ed1ef042eb83667e40f9e8988b |
| Source note | uspto-grants-2011_10 |