反应详情

A solution of 100 mg (0.248 mmol) 5-bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazole and 61 mg (0.273 mmol) N-iodosuccinimide in 3 ml acetonitrile is refluxed for 12 h. The reaction mixture is cooled to room temperature and concentrated in vacuo. The residue is purified by flash-chromatography on silica gel (hexane:EtOAc=4:1) and recrystallisation from hexane/diethyl ether afforded 82 mg of the title compound as colorless crystals.

1. concentrationconcentrated in vacuo
2. customThe residue is purified by flash-chromatography on silica gel (hexane:EtOAc=4:1) and recrystallisation from hexane/diethyl ether