Ethyl Acetate → HCID 57772088, compound

Participants

Reaction Steps

To a solution of 200 mg (0.51 mmol) 5-iodo-2-(4-isopropyl-phenyl)-7-methoxy-1H-benzoimidazole in 3 ml glacial acetic acid is slowly added 82 mg (0.51 mmol) bromine. The reaction mixture is stirred for 45 min. 30 ml EtOAc are added and this solution is washed 2n NaOH, water and brine, dried over MgSO4, filtered and concentrated in vacuo. The residue is purified by flash-chromatography on silica gel (hexane:EtOAc=3:1) and recrystallized from EtOAc/diethyl ether to afford 126 mg of the title compound as off-white crystals.

Provenance & Evidence