反应详情

A mixture of 110 mg (0.315 mmol) 2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazole-5-carbonitrile and 56 mg (0.315 mmol) N-bromosuccinimide in 5 ml acetonitrile is stirred at reflux for 3 h. Then the solvents are evaporated and the residue is purified by flash-chromatography on silica gel (hexane:EtOAc=3:1) and recrystallized from EtOAc/diethyl ether/hexane to afford 60 mg of the title compound as colorless crystals.

1. temperatureat reflux for 3 h
2. customThen the solvents are evaporated
3. customthe residue is purified by flash-chromatography on silica gel (hexane:EtOAc=3:1)
4. customrecrystallized from EtOAc/diethyl ether/hexane