Hydrogen Peroxide → HCID 57772021, compound

Participants

Reaction Steps

A mixture of 714 mg (1.32 mmol) of 2-(4-Isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-5-(2-methylsulfanyl-benzyl)-1H-benzoimidazole and 142 μl (1.39 mmol) hydrogen peroxide solution (30%) in 13 ml acetic acid is stirred at room temperature for 1.5 h. After that 25 ml EtOAc are added and this solution is washed with 4n NaOH (2×), water and sodiumhydrogensulfite solution, dried over MgSO4, filtered and concentrated in vacuo. The residue is purified by flash-chromatography on silica gel (EtOAc) to afford 496 mg of the title compound as colorless crystals.

Provenance & Evidence