Hydrogen Peroxide → HCID 11226895, compound

Participants

Reaction Steps

A mixture of 140 mg (0.252 mmol) of 4-Bromo-2-(4-isopropyl-phenyl)-5-(2-methanesulfinyl-benzyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazole and 30 μl (0.265 mmol) hydrogen peroxide solution (30%) in 3 ml acetic acid is stirred at reflux temperature for 3 h. After that the reaction mixture is allowed to cool to room temperature and 25 ml EtOAc are added and this solution is washed with 4n NaOH (2×), water and sodiumhydrogensulfite solution, dried over MgSO4, filtered and concentrated in vacuo. The residue is purified by flash-chromatography on silica gel (hexane:EtOAc=1:1) to afford 112 mg of the title compound as pale red crystals.

Provenance & Evidence