Methanesulfonyl chloride → HCID 57772049, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 330 mg (0.76 mmol) [2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazol-5-yl]-pyridin-2-yl-methanol, 0.6 ml ethyl-diisopropyl-amine and 0.25 ml methanesulfonyl chloride is stirred at 0° C. for 1 h. Then the reaction mixture is poured on water and extracted (3×) with ethyl acetate. The combined organic layers are washed with water and brine, dried over MgSO4, filtered and concentrated in vacuo to afford the title product as an oil that is used directly in the next step.

Provenance & Evidence