反应详情

A solution of 58 mg (0.13 mmol) 5-benzyl-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-4-vinyl-1H-benzoimidazole in 5 ml methanol is hydrogenated in the presence of 10 mg Raney-Nickel (B113W Degussa) at normal pressure for 25 h. The catalyst is filtered off and the filtrate is concentrated in vacuo. The residue is purified by flash-chromatography on silica gel (hexane:EtOAc=6:1) to afford 26 mg of the title compound as a white crystalline solid.

1. filtrationThe catalyst is filtered off
2. concentrationthe filtrate is concentrated in vacuo
3. customThe residue is purified by flash-chromatography on silica gel (hexane:EtOAc=6:1)