反应详情

温度

0 °C

NaBH4 (65 mg, 1.72 mmol) is added to a solution of 370 mg (0.858 mmol) 4-bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazole-5-carbaldehyde in 5 ml absolute ethanol at 0° C. The reaction mixture is stirred at 0° C. for 20 min. Then the reaction mixture is poured on water and extracted (3×) with dichloromethane/isopropanol (3:1). The combined organic layers are washed with water (2×) and brine, dried over MgSO4, filtered and concentrated in vacuo to afford 380 mg of the title compound as a pure crystalline solid.

1. additionThen the reaction mixture is poured on water
2. extractionextracted (3×) with dichloromethane/isopropanol (3:1)
3. washThe combined organic layers are washed with water (2×) and brine
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo