HCID 57772019, compound → HCID 11488543, compound

HRID 1661941Notes

Reaction equation

HRID 1661941 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]([CH2:15][CH2:16][O:17][CH3:18])[C:13]3[C:19]([O:29][CH3:30])=[CH:20][C:21]([CH:27]=O)=[C:22]([C:23]([F:26])([F:25])[F:24])[C:12]=3[N:11]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[C:31]1([Mg]Br)[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1>>[CH2:27]([C:21]1[CH:20]=[C:19]([O:29][CH3:30])[C:13]2[N:14]([CH2:15][CH2:16][O:17][CH3:18])[C:10]([C:7]3[CH:8]=[CH:9][C:4]([CH:1]([CH3:2])[CH3:3])=[CH:5][CH:6]=3)=[N:11][C:12]=2[C:22]=1[C:23]([F:25])([F:24])[F:26])[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 57772019HCID 57772019, compoundHCID 178418255HCID 178418255, compound

Product 1

HCID 11488543HCID 11488543, compound

Procedure

The title compound is prepared from 2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-benzoimidazole-5-carbaldehyde and phenylmagnesiumbromide as described in examples 35 and 51.

Sources & evidence

ORD record
ord-2a34a921a7cd46bc89fccfddcfebce7d
Source dataset
uspto-grants-2011_10
Patent number
US08030497B2

Reaction notes

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