反应详情

3.0 g (8.51 mmol) of 2-(4-Isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazole-5-carbaldehyde is dissolved in 90 ml acetic acid. Bromine (437 ul, 8.51 mmol) is added dropwise and the reaction is stirred for 5 h at RT. Ice/water is added and the reaction mixture is extracted with ethyl acetate (3×). The organic layer is washed with water (3×) and brine (2×), dried (Na2SO4) and concentrated in vacuo. The residue is purified by flash-chromatography on silica gel (hexanes/EtOAc) to give 2:08 g of colorless crystals.

1. extractionthe reaction mixture is extracted with ethyl acetate (3×)
2. washThe organic layer is washed with water (3×) and brine (2×)
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated in vacuo
5. customThe residue is purified by flash-chromatography on silica gel (hexanes/EtOAc)
6. customto give 2:08 g of colorless crystals