HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1661948Generated: October 30, 2026
Aniline → [4-Bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazol-5-ylmethyl]-phenyl-amine
https://huagongshe.com/reaction/1661948
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | methanesulfonic acid 4-bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazol-5-ylmethyl ester | HCID 57771995 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [4-Bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazol-5-ylmethyl]-phenyl-amine | HCID 57772004 | — |
Reaction Steps
To a solution of 20 mg (0.039 mmol) of methanesulfonic acid 4-bromo-2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-1H-benzoimidazol-5-ylmethyl ester in DMF is added aniline (excess) and the reaction is stirred for 1 h at 60° C. The reaction mixture is extracted with sat. NaHCO3/water. The organic layer is evaporated and the residue is purified via reversed phase RP18-chromatographie to give 3.3 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08030497B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-1c366f81070b4b2db4385a4be5139429 |
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| Source note | uspto-grants-2011_10 |
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