Sodium borohydride → HCID 57772051, compound

Participants

Reaction Steps

To a solution of 710 mg (1.69 mmol) 2-(4-isopropyl-phenyl)-7-methoxy-1-(2-methoxy-ethyl)-4-trifluoromethyl-1H-benzoimidazole-5-carbaldehyde (example 54c) in 5 ml ethanol, 128 mg (3.38 mmol) NaBH4 are added at 0° C. The mixture is stirred for 30 min at room temperature. Then the reaction mixture is poured on water and extracted (3×) with ethyl acetate. The combined organic layers are washed with water (2×) and brine, dried over MgSO4, filtered and concentrated in vacuo. The residue is crystallized from hexane/EtOAc to afford 655 mg of the title compound as a colorless crystalline solid.

Provenance & Evidence