HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1661981Generated: October 28, 2026
Hydrochloric Acid → 5-(2-fluoro-4-nitrophenoxy)-6-(pyridine-4-yl)-1H-indazole
https://huagongshe.com/reaction/1661981
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-(2-Fluoro-4-nitrophenoxy)-6-(pyridine-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole | HCID 66766866 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(2-fluoro-4-nitrophenoxy)-6-(pyridine-4-yl)-1H-indazole | HCID 66766786 | 86.3% |
Reaction Steps
To a solution of 5-(2-fluoro-4-nitrophenoxy)-6-(pyridine-4-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (2.8 g, 6.45 mmol) in EtOH (30 mL) is added HCl (concentrated 5.0 mL). The mixture is stirred at 80° C. for 2 hours. Then aqueous NaHCO3 and EtOAc are added. The organic phase is dried over anhydrous MgSO4 and concentrated. The residue is purified by silica gel column chromatography eluting with PE:EtOAc (3:1) to give the desired product (1.95 g, 86.0% yield). MS (m/z): 351.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08030302B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-1b84e0ff10d0491e9b1bc614f25a69b1 |
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| Source note | uspto-grants-2011_10 |
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