HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1661988Generated: October 30, 2026
Diethyl Ether → 1-Acetyl-5-(acetyloxy)-6-bromo-1H-indazole
https://huagongshe.com/reaction/1661988
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 6-Bromo-1H-indazol-5-ol | HCID 59159946 | — |
| Product | 1-Acetyl-5-(acetyloxy)-6-bromo-1H-indazole | HCID 66767123 | 98% |
Reaction Steps
A mixture of 6-bromo-5-hydroxy-1H-indazole (25 g, 117 mmol) in acetic acid anhydride (75 mL) is heated at 110° C. with stirring for 2 hours. After it is cooled, diethyl ether (100 mL) is added. The precipitate is collected by filtration, washed with diethyl ether (30 mL), and dried under vacuum to afford the product (34 g, 98% yield). MS (m/z): 297.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08030302B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-10c222a328d84374bbe9263e5fb2ace3 |
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| Source note | uspto-grants-2011_10 |
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