Hydrochloric Acid → HCID 68215386, compound

Participants

Reaction Steps

To a mixture of methyl N5-[(benzyloxy)carbonyl]-N2-[(1-methyl-1H-indol-2-yl)carbonyl]-L-ornithinate (13.2 g), THF (65 ml), and methanol (65 ml) was added a 1 M aqueous sodium hydroxide solution (60 ml) under ice-cooling, followed by stirring at room temperature for 3 hours. To the reaction mixture was added 1 M hydrochloric acid (60 ml) under ice-cooling, and the solvent was removed by evaporation under reduced pressure. The residue was stirred at room temperature for 14 hours, and the solid precipitated was collected by filtration and washed with water to obtain N5-[(benzyloxy)carbonyl]-N2-[(1-methyl -1H-indol-2-yl)carbonyl]-L-ornithine (11.6 g).

Provenance & Evidence