Methanol → HCID 59453924, compound

Participants

Reaction Steps

To a mixture of ethyl 1-ethyl-4-methyl-1H-pyrrole-2-carboxylate (0.66 g), methanol (5.0 ml), and THF (5.0 ml) was added a 1 M aqueous sodium hydroxide solution (5.0 ml) under ice-cooling, followed by stirring at room temperature for 8.5 days. Water was added to the reaction mixture and the solvent was removed by evaporation under reduced pressure. The residue was washed with diethyl ether, and citric acid was added to the aqueous layer under ice-cooling. The solid precipitated was collected by filtration, washed with water, and dried to obtain 1-ethyl-4-methyl-1H-pyrrole-2-carboxylic acid (0.44 g).

Provenance & Evidence