Hydrochloric Acid → HCID 67430512, compound

Participants

Reaction Steps

To a mixture of tert-butyl 3-(1-{[(benzyloxy)carbonyl]amino}cyclopentyl)propanoate (0.58 g), dioxane (17 ml), and palladium-carbon (0.12 g) was added 1 M hydrochloric acid (1.7 ml) under ice-cooling, followed by stirring at room temperature for 1 hour under a hydrogen atmosphere. The insolubles in the reaction mixture were separated by filtration through Celite and the filtrate was concentrated under reduced pressure. The residue was washed with diethyl ether to obtain tert-butyl 3-(1-aminocyclopentyl)propanoate (0.11 g).

Provenance & Evidence