Toluene → HCID 59453988, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl [(1S,2R)-2-cyanocyclopentyl]carbamate (2.8 g), toluene (50 ml), sodium azide (2.1 g), and triethylamine hydrochloride (4.5 g) was stirred at 130° C. for 24 hours. To the reaction mixture was added water (40 ml) at room temperature. The aqueous layer was separated, citric acid was added thereto under ice-cooling, and the solid precipitated was collected by filtration and washed with water to obtain tert-butyl [(1S,2R)-2-(2H-tetrazole-5-yl)cyclopentyl]carbamate (3.0 g).

Provenance & Evidence