HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1662066Generated: October 30, 2026
tert-Butanol → (1R,2S)-2-tert-Butoxycarbonylcyclopropanecarboxylic acid
https://huagongshe.com/reaction/1662066
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | (1r,5s)-3-Oxabicyclo[3.1.0]hexane-2,4-dione | HCID 12688062 | — |
| Product | (1R,2S)-2-tert-Butoxycarbonylcyclopropanecarboxylic acid | HCID 53929811 | — |
Reaction Steps
A mixture of rel-(1R,5S)-3-oxabicyclo[3.1.0]hexane-2,4-dione (1.1 g) and 2-methyl-2-propanol (10 ml) was stirred at 110° C. for 2.5 days. The reaction mixture was concentrated under reduced pressure to obtain rel-(1R,2S)-2-(tert-butoxycarbonyl)cyclopropanecarboxylic acid (1.8 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08030489B2 |
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| Source dataset | uspto-grants-2011_10 |
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| ORD ID | ord-3e6a49a9f72f40788d8e1c181141661a |
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| Source note | uspto-grants-2011_10 |
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